| 5-methyltetrahydrofolate rapidly improves endothelial function and decreases superoxide production in human vessels: effects on vascular tetrahydrobiopterin availability and … C Antoniades, C Shirodaria, N Warrick, S Cai, J de Bono, J Lee, P Leeson, ... Circulation 114 (11), 1193-1201, 2006 | 583* | 2006 |
| Critical role for tetrahydrobiopterin recycling by dihydrofolate reductase in regulation of endothelial nitric-oxide synthase coupling: relative importance of the de novo … MJ Crabtree, AL Tatham, AB Hale, NJ Alp, KM Channon Journal of Biological Chemistry 284 (41), 28128-28136, 2009 | 253 | 2009 |
| Ratio of 5, 6, 7, 8-tetrahydrobiopterin to 7, 8-dihydrobiopterin in endothelial cells determines glucose-elicited changes in NO vs. superoxide production by eNOS MJ Crabtree, CL Smith, G Lam, MS Goligorsky, SS Gross American Journal of Physiology-Heart and Circulatory Physiology 294 (4 …, 2008 | 243 | 2008 |
| Tetrahydrobiopterin in cardiovascular health and disease JK Bendall, G Douglas, E McNeill, KM Channon, MJ Crabtree Antioxidants & redox signaling 20 (18), 3040-3077, 2014 | 241 | 2014 |
| Prevention and reversal of premature endothelial cell senescence and vasculopathy in obesity-induced diabetes by ebselen SV Brodsky, O Gealekman, J Chen, F Zhang, N Togashi, M Crabtree, ... Circulation research 94 (3), 377-384, 2004 | 240 | 2004 |
| Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease MJ Crabtree, KM Channon Nitric Oxide 25 (2), 81-88, 2011 | 229 | 2011 |
| Quantitative regulation of intracellular endothelial nitric-oxide synthase (eNOS) coupling by both tetrahydrobiopterin-eNOS stoichiometry and biopterin redox status: insights … MJ Crabtree, AL Tatham, Y Al-Wakeel, N Warrick, AB Hale, S Cai, ... Journal of Biological Chemistry 284 (2), 1136-1144, 2009 | 224 | 2009 |
| Nitric oxide synthases in heart failure R Carnicer, MJ Crabtree, V Sivakumaran, B Casadei, DA Kass Antioxidants & redox signaling 18 (9), 1078-1099, 2013 | 203 | 2013 |
| Nephropathy in Zucker diabetic fat rat is associated with oxidative and nitrosative stress: prevention by chronic therapy with a peroxynitrite scavenger ebselen PN Chander, O Gealekman, SV Brodsky, S Elitok, A Tojo, M Crabtree, ... Journal of the American Society of Nephrology 15 (9), 2391-2403, 2004 | 203 | 2004 |
| Involvement of mitochondria in acetaminophen-induced apoptosis and hepatic injury: roles of cytochrome c, Bax, Bid, and caspases H El-Hassan, K Anwar, P Macanas-Pirard, M Crabtree, SC Chow, ... Toxicology and applied pharmacology 191 (2), 118-129, 2003 | 175 | 2003 |
| Nitric oxide modulates metabolic remodeling in inflammatory macrophages through TCA cycle regulation and itaconate accumulation JD Bailey, M Diotallevi, T Nicol, E McNeill, A Shaw, S Chuaiphichai, ... Cell reports 28 (1), 218-230. e7, 2019 | 170 | 2019 |
| Systemic and vascular oxidation limits the efficacy of oral tetrahydrobiopterin treatment in patients with coronary artery disease C Cunnington, T Van Assche, C Shirodaria, I Kylintireas, AC Lindsay, ... Circulation 125 (11), 1356-1366, 2012 | 170 | 2012 |
| Regulation of iNOS function and cellular redox state by macrophage Gch1 reveals specific requirements for tetrahydrobiopterin in NRF2 activation E McNeill, MJ Crabtree, N Sahgal, J Patel, S Chuaiphichai, AJ Iqbal, ... Free Radical Biology and Medicine 79, 206-216, 2015 | 152 | 2015 |
| Recoupling the cardiac nitric oxide synthases: tetrahydrobiopterin synthesis and recycling MS Alkaitis, MJ Crabtree Current heart failure reports 9, 200-210, 2012 | 150 | 2012 |
| Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency MJ Crabtree, AB Hale, KM Channon Free Radical Biology and Medicine 50 (11), 1639-1646, 2011 | 136 | 2011 |
| Hyperglycemia induces trained immunity in macrophages and their precursors and promotes atherosclerosis L Edgar, N Akbar, AT Braithwaite, T Krausgruber, H Gallart-Ayala, J Bailey, ... Circulation 144 (12), 961-982, 2021 | 133 | 2021 |
| Endothelial cell–specific reactive oxygen species production increases susceptibility to aortic dissection LM Fan, G Douglas, JK Bendall, E McNeill, MJ Crabtree, AB Hale, A Mai, ... Circulation 129 (25), 2661-2672, 2014 | 124 | 2014 |
| Endothelial-specific Nox2 overexpression increases vascular superoxide and macrophage recruitment in ApoE−/− mice G Douglas, JK Bendall, MJ Crabtree, AL Tatham, EE Carter, AB Hale, ... Cardiovascular research 94 (1), 20-29, 2012 | 113 | 2012 |
| Integrated redox sensor and effector functions for tetrahydrobiopterin-and glutathionylation-dependent endothelial nitric-oxide synthase uncoupling MJ Crabtree, R Brixey, H Batchelor, AB Hale, KM Channon Journal of Biological Chemistry 288 (1), 561-569, 2013 | 92 | 2013 |
| Endothelial cell repopulation after stenting determines in-stent neointima formation: effects of bare-metal vs. drug-eluting stents and genetic endothelial cell modification G Douglas, E Van Kampen, AB Hale, E McNeill, J Patel, MJ Crabtree, ... European heart journal 34 (43), 3378-3388, 2013 | 82 | 2013 |
Surawee ChuaiphichaiUniversity of OxfordBestätigte E-Mail-Adresse bei cardiov.ox.ac.uk
