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Xinli Hu
Xinli Hu
Director, Genetics @ Pfizer
Bestätigte E-Mail-Adresse bei pfizer.com - Startseite
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Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease
L Jostins, S Ripke, RK Weersma, RH Duerr, DP McGovern, KY Hui, ...
Nature 491 (7422), 119-124, 2012
52172012
FinnGen provides genetic insights from a well-phenotyped isolated population
MI Kurki, J Karjalainen, P Palta, TP Sipilä, K Kristiansson, KM Donner, ...
Nature 613 (7944), 508-518, 2023
10992023
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis
S Eyre, J Bowes, D Diogo, A Lee, A Barton, P Martin, A Zhernakova, ...
Nature genetics 44 (12), 1336-1340, 2012
7692012
International IBD Genetics Consortium (IIBDGC). Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease
L Jostins, S Ripke, RK Weersma, RH Duerr, DP McGovern, KY Hui, ...
Nature 491 (7422), 119-124, 2012
6302012
Automated high-dimensional flow cytometric data analysis
S Pyne, X Hu, K Wang, E Rossin, TI Lin, LM Maier, C Baecher-Allan, ...
Proceedings of the National Academy of Sciences 106 (21), 8519-8524, 2009
4972009
FinnGen: Unique genetic insights from combining isolated population and national health register data
MI Kurki, J Karjalainen, P Palta, TP Sipilä, K Kristiansson, K Donner, ...
medrxiv, 2022.03. 03.22271360, 2022
3972022
High-density mapping of the MHC identifies a shared role for HLA-DRB1* 01: 03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis
P Goyette, G Boucher, D Mallon, E Ellinghaus, L Jostins, H Huang, ...
Nature genetics 47 (2), 172-179, 2015
3382015
Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk
X Hu, AJ Deutsch, TL Lenz, S Onengut-Gumuscu, B Han, WM Chen, ...
Nature genetics 47 (8), 898-905, 2015
2782015
The role of the CD58 locus in multiple sclerosis
PL De Jager, C Baecher-Allan, LM Maier, AT Arthur, L Ottoboni, ...
Proceedings of the National Academy of Sciences 106 (13), 5264-5269, 2009
2422009
Widespread non-additive and interaction effects within HLA loci modulate the risk of autoimmune diseases
TL Lenz, AJ Deutsch, B Han, X Hu, Y Okada, S Eyre, M Knapp, ...
Nature genetics 47 (9), 1085-1090, 2015
2142015
Integrating autoimmune risk loci with gene-expression data identifies specific pathogenic immune cell subsets
X Hu, H Kim, E Stahl, R Plenge, M Daly, S Raychaudhuri
The American Journal of Human Genetics 89 (4), 496-506, 2011
1982011
Disentangling the effects of colocalizing genomic annotations to functionally prioritize non-coding variants within complex-trait loci
G Trynka, HJ Westra, K Slowikowski, X Hu, H Xu, BE Stranger, RJ Klein, ...
The American Journal of Human Genetics 97 (1), 139-152, 2015
1462015
Systematic single-variant and gene-based association testing of thousands of phenotypes in 394,841 UK Biobank exomes
KJ Karczewski, M Solomonson, KR Chao, JK Goodrich, G Tiao, W Lu, ...
Cell Genomics 2 (9), 2022
1152022
SNPsea: an algorithm to identify cell types, tissues and pathways affected by risk loci
K Slowikowski, X Hu, S Raychaudhuri
Bioinformatics 30 (17), 2496-2497, 2014
762014
A method to decipher pleiotropy by detecting underlying heterogeneity driven by hidden subgroups applied to autoimmune and neuropsychiatric diseases
B Han, JG Pouget, K Slowikowski, E Stahl, CH Lee, D Diogo, X Hu, ...
Nature genetics 48 (7), 803-810, 2016
732016
New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis
SH Lee, EM Byrne, CM Hultman, A Kähler, AAE Vinkhuyzen, S Ripke, ...
International journal of epidemiology 44 (5), 1706-1721, 2015
682015
Regulation of Gene Expression in Autoimmune Disease Loci and the Genetic Basis of Proliferation in CD4+ Effector Memory T Cells
X Hu, H Kim, T Raj, PJ Brennan, G Trynka, N Teslovich, K Slowikowski, ...
PLoS genetics 10 (6), e1004404, 2014
582014
IBDGC International, MS Silverberg, V
L Jostins, S Ripke, RK Weersma, RH Duerr, DP McGovern, KY Hui, ...
Annese, H. Hakonarson, SR Brant, G. Radford-Smith, CG Mathew, JD Rioux, EE …, 2012
562012
What have we learned from six years of GWAS in autoimmune diseases, and what is next?
X Hu, M Daly
Current opinion in immunology 24 (5), 571-575, 2012
462012
Genetic risk factors associated with preeclampsia and hypertensive disorders of pregnancy
JS Tyrmi, T Kaartokallio, AI Lokki, T Jääskeläinen, E Kortelainen, ...
JAMA cardiology 8 (7), 674-683, 2023
312023
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