John Ladbury
John Ladbury
School of Molecular and Cellular Biology, University of Leeds
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Zitiert von
Zitiert von
A landscape of driver mutations in melanoma
E Hodis, IR Watson, GV Kryukov, ST Arold, M Imielinski, JP Theurillat, ...
Cell 150 (2), 251-263, 2012
Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone
C Prodromou, SM Roe, R O'Brien, JE Ladbury, PW Piper, LH Pearl
Cell 90 (1), 65-75, 1997
Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin
SM Roe, C Prodromou, R O'Brien, JE Ladbury, PW Piper, LH Pearl
Journal of medicinal chemistry 42 (2), 260-266, 1999
ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo
B Panaretou, C Prodromou, SM Roe, R O'Brien, JE Ladbury, PW Piper, ...
The EMBO journal 17 (16), 4829-4836, 1998
Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation
T Spivak-Kroizman, MA Lemmon, I Dikic, JE Ladbury, D Pinchasi, ...
Cell 79 (6), 1015-1024, 1994
Microscale thermophoresis quantifies biomolecular interactions under previously challenging conditions
SAI Seidel, PM Dijkman, WA Lea, G van den Bogaart, ...
Methods 59 (3), 301-315, 2013
Just add water! The effect of water on the specificity of protein-ligand binding sites and its potential application to drug design
JE Ladbury
Chemistry & biology 3 (12), 973-980, 1996
The ATPase cycle of Hsp90 drives a molecular ‘clamp’via transient dimerization of the N‐terminal domains
C Prodromou, B Panaretou, S Chohan, G Siligardi, R O'Brien, JE Ladbury, ...
The EMBO journal, 2000
Regulation of Hsp90 ATPase activity by tetratricopeptide repeat (TPR)‐domain co‐chaperones
C Prodromou, G Siligardi, R O'Brien, DN Woolfson, L Regan, B Panaretou, ...
The EMBO journal, 1999
Sensing the heat: the application of isothermal titration calorimetry to thermodynamic studies of biomolecular interactions
JE Ladbury, BZ Chowdhry
Chemistry & biology 3 (10), 791-801, 1996
Two EGF molecules contribute additively to stabilization of the EGFR dimer
MA Lemmon, Z Bu, JE Ladbury, M Zhou, D Pinchasi, I Lax, DM Engelman, ...
The EMBO journal, 1997
Adding calorimetric data to decision making in lead discovery: a hot tip
JE Ladbury, G Klebe, E Freire
Nature reviews Drug discovery 9 (1), 23-27, 2010
Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression
CH Chan, JK Morrow, CF Li, Y Gao, G Jin, A Moten, LJ Stagg, JE Ladbury, ...
Cell 154 (3), 556-568, 2013
TCR binding to peptide-MHC stabilizes a flexible recognition interface
BE Willcox, GF Gao, JR Wyer, JE Ladbury, JI Bell, BK Jakobsen, ...
Immunity 10 (3), 357-365, 1999
Specific binding of Hoechst 33258 to the d (CGCAAATTTGCG) 2 duplex: calorimetric and spectroscopic studies
I Haq, JE Ladbury, BZ Chowdhry, TC Jenkins, JB Chaires
Journal of molecular biology 271 (2), 244-257, 1997
The thermodynamics of protein–ligand interaction and solvation: insights for ligand design
TSG Olsson, MA Williams, WR Pitt, JE Ladbury
Journal of molecular biology 384 (4), 1002-1017, 2008
Structure and interactions of the human programmed cell death 1 receptor
X Cheng, V Veverka, A Radhakrishnan, LC Waters, FW Muskett, ...
Journal of Biological Chemistry 288 (17), 11771-11785, 2013
Measurement of the binding of tyrosyl phosphopeptides to SH2 domains: a reappraisal.
JE Ladbury, MA Lemmon, M Zhou, J Green, MC Botfield, J Schlessinger
Proceedings of the National Academy of Sciences 92 (8), 3199-3203, 1995
A thermodynamic study of the trp repressor—operator interaction
JE Ladbury, JG Wright, JM Sturtevant, PB Sigler
Journal of molecular biology 238 (5), 669-681, 1994
TH17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26
S Meller, J Di Domizio, KS Voo, HC Friedrich, G Chamilos, D Ganguly, ...
Nature immunology 16 (9), 970-979, 2015
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