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Christopher McClendon
Christopher McClendon
Senior Principal Scientist, Pfizer
Bestätigte E-Mail-Adresse bei pfizer.com
Titel
Zitiert von
Zitiert von
Jahr
Reaching for high-hanging fruit in drug discovery at protein–protein interfaces
JA Wells, CL McClendon
Nature 450 (7172), 1001-1009, 2007
23412007
Dynamic architecture of a protein kinase
CL McClendon, AP Kornev, MK Gilson, SS Taylor
Proceedings of the National Academy of Sciences 111 (43), E4623-E4631, 2014
2942014
Quantifying correlations between allosteric sites in thermodynamic ensembles
CL McClendon, G Friedland, DL Mobley, H Amirkhani, MP Jacobson
Journal of chemical theory and computation 5 (9), 2486-2502, 2009
2542009
Turning a protein kinase on or off from a single allosteric site via disulfide trapping
JD Sadowsky, MA Burlingame, DW Wolan, CL McClendon, MP Jacobson, ...
Proceedings of the National Academy of Sciences 108 (15), 6056-6061, 2011
1692011
A dynamic hydrophobic core orchestrates allostery in protein kinases
J Kim, LG Ahuja, FA Chao, Y Xia, CL McClendon, AP Kornev, SS Taylor, ...
Science advances 3 (4), e1600663, 2017
1092017
Comparing conformational ensembles using the Kullback–Leibler divergence expansion
CL McClendon, L Hua, G Barreiro, MP Jacobson
Journal of chemical theory and computation 8 (6), 2115-2126, 2012
942012
Modeling conformational ensembles of slow functional motions in Pin1-WW
F Morcos, S Chatterjee, CL McClendon, PR Brenner, R López-Rendón, ...
PLoS computational biology 6 (12), e1001015, 2010
882010
Synchronous opening and closing motions are essential for cAMP-dependent protein kinase A signaling
AK Srivastava, LR McDonald, A Cembran, J Kim, LR Masterson, ...
Structure 22 (12), 1735-1743, 2014
752014
Discovery of novel 15-lipoxygenase activators to shift the human arachidonic acid metabolic network toward inflammation resolution
H Meng, CL McClendon, Z Dai, K Li, X Zhang, S He, E Shang, Y Liu, L Lai
Journal of Medicinal Chemistry 59 (9), 4202-4209, 2016
612016
Mutation of a kinase allosteric node uncouples dynamics linked to phosphotransfer
LG Ahuja, AP Kornev, CL McClendon, G Veglia, SS Taylor
Proceedings of the National Academy of Sciences 114 (6), E931-E940, 2017
582017
Substrate and inhibitor-induced dimerization and cooperativity in caspase-1 but not caspase-3.
D Datta*, CL McClendon*, MP Jacobson, JA Wells
The Journal of biological chemistry, 2013
492013
A new coarse-grained model for E. coli cytoplasm: accurate calculation of the diffusion coefficient of proteins and observation of anomalous diffusion
S Hasnain, CL McClendon, MT Hsu, MP Jacobson, P Bandyopadhyay
PLoS One 9 (9), e106466, 2014
472014
Decoding the interactions regulating the active state mechanics of eukaryotic protein kinases
HS Meharena, X Fan, LG Ahuja, MM Keshwani, CL McClendon, AM Chen, ...
PLoS Biology 14 (11), e2000127, 2016
442016
Cosolvent-enhanced sampling and unbiased identification of cryptic pockets suitable for structure-based drug design
D Schmidt, M Boehm, CL McClendon, R Torella, H Gohlke
Journal of chemical theory and computation 15 (5), 3331-3343, 2019
352019
Ensemble-and rigidity theory-based perturbation approach to analyze dynamic allostery
C Pfleger, A Minges, M Boehm, CL McClendon, R Torella, H Gohlke
Journal of Chemical Theory and Computation 13 (12), 6343-6357, 2017
342017
Conformational Equilibrium of N-Myristoylated cAMP-Dependent Protein Kinase A by Molecular Dynamics Simulations
A Cembran, LR Masterson, CL McClendon, SS Taylor, J Gao, G Veglia
Biochemistry, 2012
332012
Hydrogen Bond Strengths in Phosphorylated and Sulfated Amino Acid Residues
C Rapp, H Klerman, E Levine, CL McClendon
PLOS ONE, 2013
292013
Optimized lattice qcd kernels for a pentium 4 cluster
C McClendon
Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA …, 2001
28*2001
Active site conformational dynamics are coupled to catalysis in the mRNA decapping enzyme Dcp2
RA Aglietti, SN Floor, CL McClendon, MP Jacobson, JD Gross
Structure 21 (9), 1571-1580, 2013
252013
The role of tyrosine sulfation in the dimerization of the CXCR4: SDF‐1 complex
C Rapp, S Snow, T Laufer, CL McClendon
Protein Science 22 (8), 1025-1036, 2013
172013
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