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Dual targeting of p53 and c-MYC selectively eliminates leukaemic stem cells SA Abraham, LEM Hopcroft, E Carrick, ME Drotar, K Dunn, ... Nature 534 (7607), 341-346, 2016 | 244 | 2016 |
JAK2/STAT5 inhibition by nilotinib with ruxolitinib contributes to the elimination of CML CD34+ cells in vitro and in vivo P Gallipoli, A Cook, S Rhodes, L Hopcroft, H Wheadon, AD Whetton, ... Blood, The Journal of the American Society of Hematology 124 (9), 1492-1501, 2014 | 169 | 2014 |
Bone marrow niche trafficking of miR-126 controls the self-renewal of leukemia stem cells in chronic myelogenous leukemia B Zhang, LXT Nguyen, L Li, D Zhao, B Kumar, H Wu, A Lin, F Pellicano, ... Nature medicine 24 (4), 450-462, 2018 | 142 | 2018 |
Epigenetic reprogramming sensitizes CML stem cells to combined EZH2 and tyrosine kinase inhibition MT Scott, K Korfi, P Saffrey, LEM Hopcroft, R Kinstrie, F Pellicano, ... Cancer discovery 6 (11), 1248-1257, 2016 | 125 | 2016 |
Inhibition of interleukin-1 signaling enhances elimination of tyrosine kinase inhibitor–treated CML stem cells B Zhang, S Chu, P Agarwal, VL Campbell, L Hopcroft, HG Jørgensen, ... Blood, The Journal of the American Society of Hematology 128 (23), 2671-2682, 2016 | 124 | 2016 |
Targeting BCR-ABL-independent TKI resistance in chronic myeloid leukemia by mTOR and autophagy inhibition R Mitchell, LEM Hopcroft, P Baquero, EK Allan, K Hewit, D James, ... JNCI: Journal of the National Cancer Institute 110 (5), 467-478, 2018 | 101 | 2018 |
The antiproliferative activity of kinase inhibitors in chronic myeloid leukemia cells is mediated by FOXO transcription factors F Pellicano, MT Scott, GV Helgason, LEM Hopcroft, EK Allan, ... Stem cells 32 (9), 2324-2337, 2014 | 98 | 2014 |
CML cells actively evade host immune surveillance through cytokine-mediated downregulation of MHC-II expression A Tarafdar, LEM Hopcroft, P Gallipoli, F Pellicano, J Cassels, A Hair, ... Blood, The Journal of the American Society of Hematology 129 (2), 199-208, 2017 | 78 | 2017 |
The SAAPdb web resource: A large‐scale structural analysis of mutant proteins JM Hurst, LEM McMillan, CT Porter, J Allen, A Fakorede, ACR Martin Human Mutation 30 (4), 616-624, 2009 | 70 | 2009 |
CXCR2 and CXCL4 regulate survival and self-renewal of hematopoietic stem/progenitor cells A Sinclair, L Park, M Shah, M Drotar, S Calaminus, LEM Hopcroft, ... Blood, The Journal of the American Society of Hematology 128 (3), 371-383, 2016 | 66 | 2016 |
Pregnancy outcomes after SARS-CoV-2 infection in periods dominated by delta and omicron variants in Scotland: a population-based cohort study SJ Stock, E Moore, C Calvert, J Carruthers, C Denny, J Donaghy, ... The Lancet Respiratory Medicine 10 (12), 1129-1136, 2022 | 58 | 2022 |
Waning effectiveness of BNT162b2 and ChAdOx1 covid-19 vaccines over six months since second dose: OpenSAFELY cohort study using linked electronic health records EMF Horne, WJ Hulme, RH Keogh, TM Palmer, EJ Williamson, ... bmj 378, 2022 | 50 | 2022 |
hsa-mir183/EGR1–mediated regulation of E2F1 is required for CML stem/progenitor cell survival F Pellicano, L Park, LEM Hopcroft, MM Shah, L Jackson, MT Scott, ... Blood, The Journal of the American Society of Hematology 131 (14), 1532-1544, 2018 | 45 | 2018 |
Compensated pathogenic deviations: analysis of structural effects A Barešić, LEM Hopcroft, HH Rogers, JM Hurst, ACR Martin Journal of molecular biology 396 (1), 19-30, 2010 | 41 | 2010 |
A Phase II study of neoadjuvant axitinib for reducing the extent of venous tumour thrombus in clear cell renal cell cancer with venous invasion (NAXIVA) GD Stewart, SJ Welsh, S Ursprung, FA Gallagher, JO Jones, J Shields, ... British Journal of Cancer 127 (6), 1051-1060, 2022 | 40 | 2022 |
A population-based matched cohort study of early pregnancy outcomes following COVID-19 vaccination and SARS-CoV-2 infection C Calvert, J Carruthers, C Denny, J Donaghy, S Hillman, LEM Hopcroft, ... Nature Communications 13 (1), 6124, 2022 | 32 | 2022 |
Describing the population experiencing COVID-19 vaccine breakthrough following second vaccination in England: a cohort study from OpenSAFELY OpenSAFELY Collaborative, A Green, H Curtis, W Hulme, E Williamson, ... BMC medicine 20 (1), 243, 2022 | 26 | 2022 |
A population-based matched cohort study of major congenital anomalies following COVID-19 vaccination and SARS-CoV-2 infection C Calvert, J Carruthers, C Denny, J Donaghy, LEM Hopcroft, L Hopkins, ... Nature communications 14 (1), 107, 2023 | 23 | 2023 |
Cohort Profile: The COVID-19 in Pregnancy in Scotland (COPS) dynamic cohort of pregnant women to assess effects of viral and vaccine exposures on pregnancy SJ Stock, J Carruthers, C Denny, J Donaghy, A Goulding, LEM Hopcroft, ... International Journal of Epidemiology 51 (5), e245-e255, 2022 | 23 | 2022 |