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Brent Ryan
Brent Ryan
Group Leader, Research Lecturer, University of Oxford
Bestätigte E-Mail-Adresse bei dpag.ox.ac.uk - Startseite
Titel
Zitiert von
Zitiert von
Jahr
Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease
BJ Ryan, S Hoek, EA Fon, R Wade-Martins
Trends in biochemical sciences 40 (4), 200-210, 2015
5862015
Deficits in dopaminergic transmission precede neuron loss and dysfunction in a new Parkinson model
S Janezic, S Threlfell, PD Dodson, MJ Dowie, TN Taylor, D Potgieter, ...
Proceedings of the National Academy of Sciences 110 (42), E4016-E4025, 2013
3542013
ER stress and autophagic perturbations lead to elevated extracellular α-synuclein in GBA-N370S Parkinson's iPSC-derived dopamine neurons
HJR Fernandes, EM Hartfield, HC Christian, E Emmanoulidou, Y Zheng, ...
Stem cell reports 6 (3), 342-356, 2016
3502016
Mitochondrial dysfunction and mitophagy in Parkinson’s disease: from mechanism to therapy
AB Malpartida, M Williamson, DP Narendra, R Wade-Martins, BJ Ryan
Trends in biochemical sciences 46 (4), 329-343, 2021
2992021
Single-cell sequencing of iPSC-dopamine neurons reconstructs disease progression and identifies HDAC4 as a regulator of Parkinson cell phenotypes
C Lang*, KR Campbell*, BJ Ryan, P Carling, M Attar, J Vowles, ...
Cell stem cell 24 (1), 93-106. e6, 2019
1502019
Cellular α-synuclein pathology is associated with bioenergetic dysfunction in Parkinson’s iPSC-derived dopamine neurons
F Zambon, M Cherubini, HJR Fernandes, C Lang, BJ Ryan, V Volpato, ...
Human Molecular Genetics 28 (12), 2001-2013, 2019
1402019
Autoantibodies to posttranslational modifications in rheumatoid arthritis
AN Burska, L Hunt, M Boissinot, R Strollo, BJ Ryan, E Vital, A Nissim, ...
Mediators of Inflammation 2014, 2014
1212014
Measurement and meaning of markers of reactive species of oxygen, nitrogen and sulfur in healthy human subjects and patients with inflammatory joint disease
PG Winyard, B Ryan, P Eggleton, A Nissim, E Taylor, ML Lo Faro, ...
Biochemical society transactions 39 (5), 1226-1232, 2011
111*2011
Oxidative post-translational modifications and their involvement in the pathogenesis of autoimmune diseases
BJ Ryan, A Nissim, PG Winyard
Redox biology 2, 715-724, 2014
1092014
Mitochondrial dysfunction and increased glycolysis in prodromal and early Parkinson's blood cells
AM Smith, C Depp, BJ Ryan, GI Johnston, J Alegre‐Abarrategui, S Evetts, ...
Movement Disorders 33 (10), 1580-1590, 2018
892018
Extracellular calreticulin is present in the joints of patients with rheumatoid arthritis and inhibits FasL (CD95L)–mediated apoptosis of T cells
JM Tarr, PG Winyard, B Ryan, LW Harries, R Haigh, N Viner, P Eggleton
Arthritis & Rheumatism 62 (10), 2919-2929, 2010
732010
PARK2 Mutation Causes Metabolic Disturbances and Impaired Survival of Human iPSC-Derived Neurons
H Bogetofte, P Jensen, M Ryding, SI Schmidt, J Okarmus, L Ritter, ...
Frontiers in cellular neuroscience 13, 297, 2019
632019
Region-specific deficits in dopamine, but not norepinephrine, signaling in a novel A30P α-synuclein BAC transgenic mouse
TN Taylor, D Potgieter, S Anwar, SL Senior, S Janezic, S Threlfell, B Ryan, ...
Neurobiology of disease 62, 193-207, 2014
602014
A novel role for endothelial tetrahydrobiopterin in mitochondrial redox balance
J Bailey, A Shaw, R Fischer, BJ Ryan, BM Kessler, J McCullagh, ...
Free Radical Biology and Medicine 104, 214-225, 2017
592017
Oxidative and other posttranslational modifications in extracellular vesicle biology
K Szabó-Taylor, B Ryan, X Osteikoetxea, TG Szabó, B Sódar, M Holub, ...
Seminars in cell & developmental biology 40, 8-16, 2015
552015
α-Synuclein and mitochondrial bioenergetics regulate tetrahydrobiopterin levels in a human dopaminergic model of Parkinson disease
BJ Ryan, LL Lourenço-Venda, MJ Crabtree, AB Hale, KM Channon, ...
Free Radical Biology and Medicine 67, 58-68, 2014
362014
Perturbations in RhoA signalling cause altered migration and impaired neuritogenesis in human iPSC-derived neural cells with PARK2 mutation
H Bogetofte, P Jensen, J Okarmus, SI Schmidt, M Agger, M Ryding, ...
Neurobiology of Disease 132, 104581, 2019
352019
Protein-protein interaction networks identify targets which rescue the MPP+ cellular model of Parkinson’s disease
H Keane*, BJ Ryan*, B Jackson, A Whitmore, R Wade-Martins
Scientific reports 5 (1), 17004, 2015
342015
Detection and isolation of human serum autoantibodies that recognize oxidatively modified autoantigens
P Eggleton, A Nissim, BJ Ryan, M Whiteman, PG Winyard
Free radical biology and medicine 57, 79-91, 2013
342013
A requirement for Gch1 and tetrahydrobiopterin in embryonic development
G Douglas, AB Hale, MJ Crabtree, BJ Ryan, A Hansler, K Watschinger, ...
Developmental biology 399 (1), 129-138, 2015
322015
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