Brent Ryan
Brent Ryan
Group Leader, Research Lecturer, University of Oxford
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Zitiert von
Zitiert von
Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease
BJ Ryan, S Hoek, EA Fon, R Wade-Martins
Trends in biochemical sciences 40 (4), 200-210, 2015
Deficits in dopaminergic transmission precede neuron loss and dysfunction in a new Parkinson model
S Janezic, S Threlfell, PD Dodson, MJ Dowie, TN Taylor, D Potgieter, ...
Proceedings of the National Academy of Sciences 110 (42), E4016-E4025, 2013
ER stress and autophagic perturbations lead to elevated extracellular α-synuclein in GBA-N370S Parkinson's iPSC-derived dopamine neurons
HJR Fernandes, EM Hartfield, HC Christian, E Emmanoulidou, Y Zheng, ...
Stem cell reports 6 (3), 342-356, 2016
Mitochondrial dysfunction and mitophagy in Parkinson’s disease: from mechanism to therapy
AB Malpartida, M Williamson, DP Narendra, R Wade-Martins, BJ Ryan
Trends in biochemical sciences 46 (4), 329-343, 2021
Single-cell sequencing of iPSC-dopamine neurons reconstructs disease progression and identifies HDAC4 as a regulator of Parkinson cell phenotypes
C Lang*, KR Campbell*, BJ Ryan, P Carling, M Attar, J Vowles, ...
Cell stem cell 24 (1), 93-106. e6, 2019
Cellular α-synuclein pathology is associated with bioenergetic dysfunction in Parkinson’s iPSC-derived dopamine neurons
F Zambon, M Cherubini, HJR Fernandes, C Lang, BJ Ryan, V Volpato, ...
Human Molecular Genetics 28 (12), 2001-2013, 2019
Autoantibodies to posttranslational modifications in rheumatoid arthritis
AN Burska, L Hunt, M Boissinot, R Strollo, BJ Ryan, E Vital, A Nissim, ...
Mediators of Inflammation 2014, 2014
Measurement and meaning of markers of reactive species of oxygen, nitrogen and sulfur in healthy human subjects and patients with inflammatory joint disease
PG Winyard, B Ryan, P Eggleton, A Nissim, E Taylor, ML Lo Faro, ...
Biochemical society transactions 39 (5), 1226-1232, 2011
Oxidative post-translational modifications and their involvement in the pathogenesis of autoimmune diseases
BJ Ryan, A Nissim, PG Winyard
Redox biology 2, 715-724, 2014
Mitochondrial dysfunction and increased glycolysis in prodromal and early Parkinson's blood cells
AM Smith, C Depp, BJ Ryan, GI Johnston, J Alegre‐Abarrategui, S Evetts, ...
Movement Disorders 33 (10), 1580-1590, 2018
Extracellular calreticulin is present in the joints of patients with rheumatoid arthritis and inhibits FasL (CD95L)–mediated apoptosis of T cells
JM Tarr, PG Winyard, B Ryan, LW Harries, R Haigh, N Viner, P Eggleton
Arthritis & Rheumatism 62 (10), 2919-2929, 2010
PARK2 Mutation Causes Metabolic Disturbances and Impaired Survival of Human iPSC-Derived Neurons
H Bogetofte, P Jensen, M Ryding, SI Schmidt, J Okarmus, L Ritter, ...
Frontiers in cellular neuroscience 13, 297, 2019
Region-specific deficits in dopamine, but not norepinephrine, signaling in a novel A30P α-synuclein BAC transgenic mouse
TN Taylor, D Potgieter, S Anwar, SL Senior, S Janezic, S Threlfell, B Ryan, ...
Neurobiology of disease 62, 193-207, 2014
A novel role for endothelial tetrahydrobiopterin in mitochondrial redox balance
J Bailey, A Shaw, R Fischer, BJ Ryan, BM Kessler, J McCullagh, ...
Free Radical Biology and Medicine 104, 214-225, 2017
Oxidative and other posttranslational modifications in extracellular vesicle biology
K Szabó-Taylor, B Ryan, X Osteikoetxea, TG Szabó, B Sódar, M Holub, ...
Seminars in cell & developmental biology 40, 8-16, 2015
α-Synuclein and mitochondrial bioenergetics regulate tetrahydrobiopterin levels in a human dopaminergic model of Parkinson disease
BJ Ryan, LL Lourenço-Venda, MJ Crabtree, AB Hale, KM Channon, ...
Free Radical Biology and Medicine 67, 58-68, 2014
Perturbations in RhoA signalling cause altered migration and impaired neuritogenesis in human iPSC-derived neural cells with PARK2 mutation
H Bogetofte, P Jensen, J Okarmus, SI Schmidt, M Agger, M Ryding, ...
Neurobiology of Disease 132, 104581, 2019
Protein-protein interaction networks identify targets which rescue the MPP+ cellular model of Parkinson’s disease
H Keane*, BJ Ryan*, B Jackson, A Whitmore, R Wade-Martins
Scientific reports 5 (1), 17004, 2015
Detection and isolation of human serum autoantibodies that recognize oxidatively modified autoantigens
P Eggleton, A Nissim, BJ Ryan, M Whiteman, PG Winyard
Free radical biology and medicine 57, 79-91, 2013
A requirement for Gch1 and tetrahydrobiopterin in embryonic development
G Douglas, AB Hale, MJ Crabtree, BJ Ryan, A Hansler, K Watschinger, ...
Developmental biology 399 (1), 129-138, 2015
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