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Jonathan K. Watts
Jonathan K. Watts
Professor, RNA Therapeutics Institute, UMass Chan Medical School
Bestätigte E-Mail-Adresse bei umassmed.edu - Startseite
Titel
Zitiert von
Zitiert von
Jahr
The chemical evolution of oligonucleotide therapies of clinical utility
A Khvorova, JK Watts
Nature biotechnology 35 (3), 238-248, 2017
10882017
Chemically modified siRNA: tools and applications
JK Watts, GF Deleavey, MJ Damha
Drug discovery today 13 (19-20), 842-855, 2008
5602008
Silencing disease genes in the laboratory and the clinic
JK Watts, DR Corey
The Journal of pathology 226 (2), 365-379, 2012
553*2012
Enhancer RNA facilitates NELF release from immediate early genes
K Schaukowitch, JY Joo, X Liu, JK Watts, C Martinez, TK Kim
Molecular cell 56 (1), 29-42, 2014
4612014
RNA therapeutics on the rise
F Wang, T Zuroske, JK Watts
Nature Reviews Drug Discovery 19, 441-442, 2020
2242020
Synergistic effects between analogs of DNA and RNA improve the potency of siRNA-mediated gene silencing
GF Deleavey, JK Watts, T Alain, F Robert, A Kalota, V Aishwarya, ...
Nucleic acids research 38 (13), 4547-4557, 2010
1252010
Suppression of mutant C9orf72 expression by a potent mixed backbone antisense oligonucleotide
H Tran, MP Moazami, H Yang, D McKenna-Yasek, CL Douthwright, ...
Nature medicine 28 (1), 117-124, 2022
1192022
Oligonucleotide therapeutics: chemistry, delivery and clinical progress
VK Sharma, JK Watts
Future medicinal chemistry 7 (16), 2221-2242, 2015
1172015
Energetically important C− H··· F− C pseudohydrogen bonding in water: evidence and application to rational design of oligonucleotides with high binding affinity
MY Anzahaee, JK Watts, NR Alla, AW Nicholson, MJ Damha
Journal of the American Chemical Society 133 (4), 728-731, 2011
1082011
2′-Fluoro-4′-thioarabino-modified oligonucleotides: conformational switches linked to siRNA activity
JK Watts, N Choubdar, K Sadalapure, F Robert, AS Wahba, J Pelletier, ...
Nucleic acids research 35 (5), 1441-1451, 2007
1082007
Heavily and fully modified RNAs guide efficient SpyCas9-mediated genome editing
A Mir, JF Alterman, MR Hassler, AJ Debacker, E Hudgens, D Echeverria, ...
Nature Communications 9, 2641, 2018
1062018
The NIH somatic cell genome editing program
K Saha, EJ Sontheimer, PJ Brooks, MR Dwinell, CA Gersbach, DR Liu, ...
Nature 592 (7853), 195-204, 2021
1042021
Chemical modification of siRNA
GF Deleavey, JK Watts, MJ Damha
Current Protocols in Nucleic Acid Chemistry 39 (1), 16.3. 1-16.3. 22, 2009
922009
Differential stability of 2′ F-ANA• RNA and ANA• RNA hybrid duplexes: roles of structure, pseudohydrogen bonding, hydration, ion uptake and flexibility
JK Watts, N Martín-Pintado, I Gomez-Pinto, J Schwartzentruber, G Portella, ...
Nucleic acids research 38 (7), 2498-2511, 2010
912010
Clinical status of duplex RNA
JK Watts, DR Corey
Bioorganic & medicinal chemistry letters 20 (11), 3203-3207, 2010
892010
Generation of novel hybrid aptamer-molecularly imprinted polymeric nanoparticles
A Poma, H Brahmbhatt, HM Pendergraff, JK Watts, NW Turner
Wiley, 2015
882015
2′ F-Arabinonucleic acids (2′ F-ANA)—History, properties, and new frontiers
JK Watts, MJ Damha
Canadian Journal of Chemistry 86 (7), 641-656, 2008
792008
Studies on the hydrolytic stability of 2′-fluoroarabinonucleic acid (2′ F-ANA)
JK Watts, A Katolik, J Viladoms, MJ Damha
Organic & biomolecular chemistry 7 (9), 1904-1910, 2009
752009
Allele-selective inhibition of ataxin-3 (ATX3) expression by antisense oligomers and duplex RNAs
J Hu, KT Gagnon, J Liu, JK Watts, J Syeda-Nawaz, CF Bennett, ...
Walter de Gruyter 392 (4), 315-325, 2011
702011
Oligonucleotides targeting TCF4 triplet repeat expansion inhibit RNA foci and mis-splicing in Fuchs’ dystrophy
J Hu, Z Rong, X Gong, Z Zhou, VK Sharma, C Xing, JK Watts, DR Corey, ...
Human molecular genetics 27 (6), 1015-1026, 2018
672018
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