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Lewis Cantley
Lewis Cantley
Dana Farber Cancer Center and Harvard Medical School
Bestätigte E-Mail-Adresse bei med.cornell.edu
Titel
Zitiert von
Zitiert von
Jahr
Understanding the Warburg effect: the metabolic requirements of cell proliferation
MG Vander Heiden, LC Cantley, CB Thompson
science 324 (5930), 1029-1033, 2009
176372009
AKT/PKB signaling: navigating downstream
BD Manning, LC Cantley
Cell 129 (7), 1261-1274, 2007
75772007
The phosphoinositide 3-kinase pathway
LC Cantley
Science 296 (5573), 1655-1657, 2002
74482002
MET Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 Signaling
JA Engelman, K Zejnullahu, T Mitsudomi, Y Song, C Hyland, JO Park, ...
science 316 (5827), 1039-1043, 2007
55212007
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
L Dang, DW White, S Gross, BD Bennett, MA Bittinger, EM Driggers, ...
Nature 462 (7274), 739-744, 2009
48762009
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
JA Engelman, J Luo, LC Cantley
Nature Reviews Genetics 7 (8), 606-619, 2006
40712006
SH2 domains recognize specific phosphopeptide sequences
S Zhou, SE Shoelson, M Chaudhuri, G Gish, T Pawson, WG Haser, F King, ...
Cell 72 (5), 767-778, 1993
35691993
Oncogenes and signal transduction
LC Cantley, KR Auger, C Carpenter, B Duckworth, A Graziani, R Kapeller, ...
Cell 64 (2), 281-302, 1991
35531991
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
HR Christofk, MG Vander Heiden, MH Harris, A Ramanathan, ...
Nature 452 (7184), 230-233, 2008
32962008
Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
GM DeNicola, FA Karreth, TJ Humpton, A Gopinathan, C Wei, K Frese, ...
Nature 475 (7354), 106-109, 2011
2971*2011
New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
LC Cantley, BG Neel
Proceedings of the National Academy of Sciences 96 (8), 4240-4245, 1999
27701999
Ras, PI (3) K and mTOR signalling controls tumour cell growth
RJ Shaw, LC Cantley
Nature 441 (7092), 424-430, 2006
26582006
The PI3K pathway in human disease
DA Fruman, H Chiu, BD Hopkins, S Bagrodia, LC Cantley, RT Abraham
Cell 170 (4), 605-635, 2017
24982017
PI3K pathway alterations in cancer: variations on a theme
TL Yuan, LC Cantley
Oncogene 27 (41), 5497-5510, 2008
24582008
The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin
RJ Shaw, KA Lamia, D Vasquez, SH Koo, N Bardeesy, RA DePinho, ...
Science 310 (5754), 1642-1646, 2005
24262005
PI3K: downstream AKTion blocks apoptosis
TF Franke, DR Kaplan, LC Cantley
Cell 88 (4), 435-437, 1997
21951997
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress
RJ Shaw, M Kosmatka, N Bardeesy, RL Hurley, LA Witters, RA DePinho, ...
Proceedings of the National Academy of Sciences 101 (10), 3329-3335, 2004
21832004
Phosphoinositide kinases
DA Fruman, RE Meyers, LC Cantley
Annual review of biochemistry 67 (1), 481-507, 1998
21621998
Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism
H Ying, AC Kimmelman, CA Lyssiotis, S Hua, GC Chu, ...
Cell 149 (3), 656-670, 2012
21442012
Bidirectional transport of amino acids regulates mTOR and autophagy
P Nicklin, P Bergman, B Zhang, E Triantafellow, H Wang, B Nyfeler, ...
Cell 136 (3), 521-534, 2009
20532009
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