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Nicholas C. Wu
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A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV
M Yuan, NC Wu, X Zhu, CCD Lee, RTY So, H Lv, CKP Mok, IA Wilson
Science 368 (6491), 630-633, 2020
15732020
Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model
TF Rogers, F Zhao, D Huang, N Beutler, A Burns, W He, O Limbo, C Smith, ...
Science 369 (6506), 956-963, 2020
13632020
Structural basis of a shared antibody response to SARS-CoV-2
M Yuan, H Liu, NC Wu, CCD Lee, X Zhu, F Zhao, D Huang, W Yu, Y Hua, ...
Science, 2020
5542020
Cross-reactive antibody response between SARS-CoV-2 and SARS-CoV infections
H Lv, NC Wu, OTY Tsang, M Yuan, RAPM Perera, WS Leung, RTY So, ...
Cell reports 31 (9), 107725, 2020
4532020
Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling
AG York, KJ Williams, JP Argus, QD Zhou, G Brar, L Vergnes, EE Gray, ...
Cell 163 (7), 1716-1729, 2015
3882015
Serological assays for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), March 2020
RAPM Perera, CKP Mok, OTY Tsang, H Lv, RLW Ko, NC Wu, M Yuan, ...
Eurosurveillance 25 (16), 2000421, 2020
3842020
Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants
M Yuan, D Huang, CCD Lee, NC Wu, AM Jackson, X Zhu, H Liu, L Peng, ...
Science 373 (6556), 818-823, 2021
3592021
Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape
PA Koenig, H Das, H Liu, BM Kümmerer, FN Gohr, LM Jenster, ...
Science 371 (6530), eabe6230, 2021
3432021
A comprehensive biophysical description of pairwise epistasis throughout an entire protein domain
CA Olson, NC Wu, R Sun
Current Biology 24 (22), 2643-2651, 2014
3332014
A therapeutic non-self-reactive SARS-CoV-2 antibody protects from lung pathology in a COVID-19 hamster model
J Kreye, SM Reincke, HC Kornau, E Sánchez-Sendin, VM Corman, H Liu, ...
Cell 183 (4), 1058-1069. e19, 2020
3322020
A structural explanation for the low effectiveness of the seasonal influenza H3N2 vaccine.
NC Wu, SJ Zost, AJ Thompson, D Oyen, CM Nycholat, R McBride, ...
PLoS pathogens 13 (10), e1006682, 2017
2432017
A Broadly Neutralizing Antibody Targets the Dynamic HIV Envelope Trimer Apex via a Long, Rigidified, and Anionic β-Hairpin Structure
JH Lee, R Andrabi, CY Su, A Yasmeen, JP Julien, L Kong, NC Wu, ...
Immunity 46 (4), 690-702, 2017
2412017
Adaptation in protein fitness landscapes is facilitated by indirect paths
NC Wu, L Dai, CA Olson, JO Lloyd-Smith, R Sun
eLife 5, e16965, 2016
2372016
Cross-neutralization of a SARS-CoV-2 antibody to a functionally conserved site is mediated by avidity
H Liu, NC Wu, M Yuan, S Bangaru, JL Torres, TG Caniels, ...
Immunity 53 (6), 1272-1280. e5, 2020
2112020
Recognition of the SARS-CoV-2 receptor binding domain by neutralizing antibodies
M Yuan, H Liu, NC Wu, IA Wilson
Biochemical and Biophysical Research Communications 538, 192-203, 2021
1822021
Deep mutational scanning of hemagglutinin helps predict evolutionary fates of human H3N2 influenza variants
JM Lee, J Huddleston, MB Doud, KA Hooper, NC Wu, T Bedford, ...
Proceedings of the National Academy of Sciences 115 (35), E8276-E8285, 2018
1792018
An alternative binding mode of IGHV3-53 antibodies to the SARS-CoV-2 receptor binding domain
NC Wu, M Yuan, H Liu, CCD Lee, X Zhu, S Bangaru, JL Torres, ...
Cell reports 33 (3), 108274, 2020
1552020
A perspective on the structural and functional constraints for immune evasion: Insights from influenza virus
NC Wu, IA Wilson
Journal of Molecular Biology 429 (17), 2694-2709, 2017
1542017
Influenza hemagglutinin structures and antibody recognition
NC Wu, IA Wilson
Cold Spring Harbor perspectives in medicine 10 (8), a038778, 2020
1262020
Chromosomal DNA deletion confers phage resistance to Pseudomonas aeruginosa
S Le, X Yao, S Lu, Y Tan, X Rao, M Li, X Jin, J Wang, Y Zhao, NC Wu, ...
Scientific reports 4, 4738, 2014
1262014
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