Structural basis for benzothiazinone-mediated killing of Mycobacterium tuberculosis J Neres, F Pojer, E Molteni, LR Chiarelli, N Dhar, S Boy-Röttger, S Buroni, ... Science translational medicine 4 (150), 150ra121-150ra121, 2012 | 208 | 2012 |
Clinical Isolates of Mycobacterium tuberculosis in Four European Hospitals Are Uniformly Susceptible to Benzothiazinones MR Pasca, G Degiacomi, ALJL Ribeiro, F Zara, P De Mori, B Heym, ... Antimicrobial agents and chemotherapy 54 (4), 1616-1618, 2010 | 131 | 2010 |
Mycobacterium abscessus, an Emerging and Worrisome Pathogen among Cystic Fibrosis Patients G Degiacomi, JC Sammartino, LR Chiarelli, O Riabova, V Makarov, ... International journal of molecular sciences 20 (23), 5868, 2019 | 117 | 2019 |
Essentiality of mmpL3 and impact of its silencing on Mycobacterium tuberculosis gene expression G Degiacomi, A Benjak, J Madacki, F Boldrin, R Provvedi, G Palù, ... Scientific reports 7 (1), 43495, 2017 | 115 | 2017 |
Biological and structural characterization of the Mycobacterium smegmatis nitroreductase NfnB, and its role in benzothiazinone resistance G Manina, M Bellinzoni, MR Pasca, J Neres, A Milano, ... Molecular microbiology 77 (5), 1172-1185, 2010 | 95 | 2010 |
PknG senses amino acid availability to control metabolism and virulence of Mycobacterium tuberculosis B Rieck, G Degiacomi, M Zimmermann, A Cascioferro, F Boldrin, ... PLoS pathogens 13 (5), e1006399, 2017 | 89 | 2017 |
Thiophenecarboxamide derivatives activated by EthA kill Mycobacterium tuberculosis by inhibiting the CTP synthetase PyrG G Mori, LR Chiarelli, M Esposito, V Makarov, M Bellinzoni, RC Hartkoorn, ... Chemistry & biology 22 (7), 917-927, 2015 | 75 | 2015 |
GarA is an essential regulator of metabolism in Mycobacterium tuberculosis M Ventura, B Rieck, F Boldrin, G Degiacomi, M Bellinzoni, N Barilone, ... Molecular microbiology 90 (2), 356-366, 2013 | 66 | 2013 |
Analogous Mechanisms of Resistance to Benzothiazinones and Dinitrobenzamides in Mycobacterium smegmatis AL de Jesus Lopes Ribeiro, G Degiacomi, F Ewann, S Buroni, ... PloS one 6 (11), e26675, 2011 | 66 | 2011 |
In vitro study of bedaquiline resistance in Mycobacterium tuberculosis multi-drug resistant clinical isolates G Degiacomi, JC Sammartino, V Sinigiani, P Marra, A Urbani, MR Pasca Frontiers in microbiology 11, 559469, 2020 | 59 | 2020 |
Promiscuous targets for antitubercular drug discovery: The paradigm of DprE1 and MmpL3 G Degiacomi, JM Belardinelli, MR Pasca, E De Rossi, G Riccardi, ... Applied Sciences 10 (2), 623, 2020 | 50 | 2020 |
The Phosphatidyl-myo-Inositol Mannosyltransferase PimA Is Essential for Mycobacterium tuberculosis Growth In Vitro and In Vivo F Boldrin, M Ventura, G Degiacomi, S Ravishankar, C Sala, Z Svetlikova, ... Journal of bacteriology 196 (19), 3441-3451, 2014 | 49 | 2014 |
Whole cell screen based identification of spiropiperidines with potent antitubercular properties SJ Tantry, G Degiacomi, S Sharma, L kumar Jena, A Narayan, S Guptha, ... Bioorganic & medicinal chemistry letters 25 (16), 3234-3245, 2015 | 46 | 2015 |
A multitarget approach to drug discovery inhibiting Mycobacterium tuberculosis PyrG and PanK LR Chiarelli, G Mori, BS Orena, M Esposito, T Lane, ... Scientific reports 8 (1), 3187, 2018 | 43 | 2018 |
A phenotypic based target screening approach delivers new antitubercular CTP synthetase inhibitors M Esposito, S Szadocka, G Degiacomi, BS Orena, G Mori, V Piano, ... ACS Infectious Diseases 3 (6), 428-437, 2017 | 33 | 2017 |
Micrococcin P1–A bactericidal thiopeptide active against Mycobacterium tuberculosis G Degiacomi, Y Personne, G Mondésert, X Ge, CS Mandava, ... Tuberculosis 100, 95-101, 2016 | 30 | 2016 |
The antibacterial prodrug activator Rv2466c is a mycothiol-dependent reductase in the oxidative stress response of Mycobacterium tuberculosis LA Rosado, K Wahni, G Degiacomi, B Pedre, D Young, AG De la Rubia, ... Journal of Biological Chemistry 292 (32), 13097-13110, 2017 | 28 | 2017 |
Towards real-time and affordable strain-level metagenomics-based foodborne outbreak investigations using Oxford nanopore sequencing technologies FE Buytaers, A Saltykova, S Denayer, B Verhaegen, K Vanneste, ... Frontiers in Microbiology 12, 738284, 2021 | 22 | 2021 |
First triclosan-based macrocyclic inhibitors of InhA enzyme F Rodriguez, N Saffon, JC Sammartino, G Degiacomi, MR Pasca, ... Bioorganic Chemistry 95, 103498, 2020 | 20 | 2020 |
A Coumarin-Based Analogue of Thiacetazone as Dual Covalent Inhibitor and Potential Fluorescent Label of HadA in Mycobacterium tuberculosis A Farjallah, LR Chiarelli, M Forbak, G Degiacomi, M Danel, F Goncalves, ... ACS infectious diseases 7 (3), 552-565, 2021 | 14 | 2021 |