Hugo J R Fernandes
Hugo J R Fernandes
Group Leader & Principal Investigator, University of Oxford
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ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons
HJR Fernandes, EM Hartfield, HC Christian, E Emmanoulidou, Y Zheng, ...
Stem cell reports 6 (3), 342-356, 2016
Physiological characterisation of human iPS-derived dopaminergic neurons
EM Hartfield, M Yamasaki-Mann, HJ Ribeiro Fernandes, J Vowles, ...
PloS one 9 (2), e87388, 2014
Cellular α-synuclein pathology is associated with bioenergetic dysfunction in Parkinson’s iPSC-derived dopamine neurons
F Zambon, M Cherubini, HJR Fernandes, C Lang, BJ Ryan, V Volpato, ...
Human Molecular Genetics 28 (12), 2001-2013, 2019
Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing
FH Siddiqi, FM Menzies, A Lopez, E Stamatakou, C Karabiyik, R Ureshino, ...
Nature communications 10 (1), 1817, 2019
Delineating nonmotor symptoms in early Parkinson's disease and first‐degree relatives
F Baig, M Lawton, M Rolinski, C Ruffmann, K Nithi, SG Evetts, ...
Movement Disorders 30 (13), 1759-1766, 2015
Single-cell transcriptomics of Parkinson’s disease human in vitro models reveals dopamine neuron-specific stress responses
HJR Fernandes, N Patikas, S Foskolou, SF Field, JE Park, ML Byrne, ...
Cell Reports 33 (2), 108263, 2020
Cellular reprogramming: a new approach to modelling Parkinson's disease
EM Hartfield, HJR Fernandes, J Vowles, SA Cowley, R Wade-Martins
Biochemical Society transactions 40 (5), 1152-1157, 2012
Variant U1 snRNAs are implicated in human pluripotent stem cell maintenance and neuromuscular disease
P Vazquez-Arango, J Vowles, C Browne, E Hartfield, HJR Fernandes, ...
Nucleic acids research 44 (22), 10960-10973, 2016
MicroExonator enables systematic discovery and quantification of microexons across mouse embryonic development
GE Parada, R Munita, I Georgakopoulos-Soares, HJR Fernandes, ...
Genome biology 22, 1-26, 2021
Development and application of high-throughput single cell lipid profiling: a study of SNCA-A53T human dopamine neurons
SG Snowden, HJR Fernandes, J Kent, S Foskolou, P Tate, SF Field, ...
Iscience 23 (11), 101703, 2020
Beyond the lysosome: Cholesterol role on endoplasmic reticulum and lipid droplets in Parkinson's disease
HJR Fernandes
Movement Disorders 33 (2), 342-342, 2018
Commentary: Parkinson disease-linked GBA mutation effects reversed by molecular chaperones in human cell and fly models
HJR Fernandes, BJ Ryan, R Wade-Martins
Frontiers in Neuroscience 10, 578, 2016
A novel post-translational proteomics platform identifies neurite outgrowth impairments in Parkinson’s disease GBA-N370S dopamine neurons
H Bogetofte, BJ Ryan, P Jensen, DLE Vergoossen, MB Barnkob, L Kiani, ...
bioRxiv, 2021.06. 30.450333, 2021
Post-translational proteomics platform identifies neurite outgrowth impairments in Parkinson’s disease GBA-N370S dopamine neurons
H Bogetofte, BJ Ryan, P Jensen, SI Schmidt, DLE Vergoossen, ...
Cell Reports 42 (3), 2023
CRISPR-Cas9 genetic screen leads to the discovery of L-Moses, a KAT2B inhibitor that attenuates Tunicamycin-mediated neuronal cell death
S Pavlou, S Foskolou, N Patikas, SF Field, EK Papachristou, CD Santos, ...
Scientific Reports 13 (1), 3934, 2023
Mitochondrial and Endoplasmic Reticulum Stress Trigger Triglyceride Accumulation in Models of Parkinson’s Disease Independent of Mutations in MAPT
HJR Fernandes, JP Kent, M Bruntraeger, AR Bassett, A Koulman, ...
Metabolites 13 (1), 112, 2023
Surface charge and dynamic mechanoelectrical stimuli improves adhesion, proliferation and differentiation of neuron-like cells
T Marques-Almeida, HJR Fernandes, S Lanceros-Mendez, C Ribeiro
Journal of Materials Chemistry B 11 (1), 144-153, 2023
F Baig, M Lawton, M Rolinski, C Ruffmann, K Nithi, S Evetts, H Fernandes, ...
Journal of Neurology, Neurosurgery & Psychiatry 86 (11), e4-e4, 2015
Dual proteostasis effect of glucocerebrosidase in the pathology of Parkinson's disease using patient derived induced pluripotent stem cells
HJ Fernandes, E Hartfield, J Badger, J Vowles, S Evetts, K Talbot, M Hu, ...
Society for Neuroscience, 43rd Annual Meeting, Nanosymposia Presentation 43, 2013
Elucidating the role of GBA in the pathology of Parkinson's disease using human induced pluripotent stem cells derived from patients
HJ Fernandes, E Hartfield, J Vowles, S Evetts, K Talbot, M Hu, S Cowley, ...
Society for Neuroscience, 41st Annual Meeting, Nanosymposia Presentation 41, 2011
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