Muscle strength and size are associated with motor unit connectivity in aged mice KA Sheth, CC Iyer, CG Wier, AE Crum, A Bratasz, SJ Kolb, BC Clark, ... Neurobiology of aging 67, 128-136, 2018 | 94 | 2018 |
Electrophysiological biomarkers in spinal muscular atrophy: proof of concept WD Arnold, PN Porensky, VL McGovern, CC Iyer, S Duque, X Li, K Meyer, ... Annals of clinical and translational neurology 1 (1), 34, 2014 | 76 | 2014 |
SMN expression is required in motor neurons to rescue electrophysiological deficits in the SMNΔ7 mouse model of SMA VL McGovern, CC Iyer, WD Arnold, SE Gombash, PG Zaworski, ... Human Molecular Genetics 24 (19), 5524-5541, 2015 | 65 | 2015 |
Low levels of Survival Motor Neuron protein are sufficient for normal muscle function in the SMNΔ7 mouse model of SMA CC Iyer, VL McGovern, JD Murray, SE Gombash, PG Zaworski, KD Foust, ... Human molecular genetics 24 (21), 6160-6173, 2015 | 60 | 2015 |
SMN deficiency disrupts gastrointestinal and enteric nervous system function in mice SE Gombash, CJ Cowley, JA Fitzgerald, CC Iyer, D Fried, VL McGovern, ... Human molecular genetics 24 (13), 3847-3860, 2015 | 60 | 2015 |
HuD and the survival motor neuron protein interact in motoneurons and are essential for motoneuron development, function, and mRNA regulation PQ Duy, M An, J Talbot, CC Iyer, M Wolman, CE Beattie Journal of Neuroscience 37 (48), 11559-11571, 2017 | 42 | 2017 |
Neuromuscular junction transmission failure is a late phenotype in aging mice D Chugh, CC Iyer, X Wang, P Bobbili, MM Rich, WD Arnold Neurobiology of aging 86, 182-190, 2020 | 33 | 2020 |
The m6A methyltransferase METTL3 regulates muscle maintenance and growth in mice JM Petrosino, SA Hinger, VA Golubeva, JM Barajas, LE Dorn, CC Iyer, ... Nature Communications 13 (1), 168, 2022 | 29 | 2022 |
Early‐onset aging and mitochondrial defects associated with loss of histone acetyltransferase 1 (Hat1) P Nagarajan, PA Agudelo Garcia, CC Iyer, LV Popova, WD Arnold, ... Aging cell 18 (5), e12992, 2019 | 25 | 2019 |
Muscle contractility dysfunction precedes loss of motor unit connectivity in SOD1 (G93A) mice CG Wier, AE Crum, AB Reynolds, CC Iyer, D Chugh, MS Palettas, ... Muscle & nerve 59 (2), 254-262, 2019 | 22 | 2019 |
Deletion of atrophy enhancing genes fails to ameliorate the phenotype in a mouse model of spinal muscular atrophy CC Iyer, VL McGovern, DO Wise, DJ Glass, AHM Burghes Neuromuscular Disorders 24 (5), 436-444, 2014 | 17 | 2014 |
Mild SMN missense alleles are only functional in the presence of SMN2 in mammals CC Iyer, KM Corlett, A Massoni-Laporte, SI Duque, N Madabusi, S Tisdale, ... Human Molecular Genetics 27 (19), 3404-3416, 2018 | 12 | 2018 |
Normalization of patient-identified plasma biomarkers in SMNΔ7 mice following postnatal SMN restoration WD Arnold, S Duque, CC Iyer, P Zaworski, VL McGovern, SJ Taylor, ... PloS one 11 (12), e0167077, 2016 | 11 | 2016 |
Follistatin-induced muscle hypertrophy in aged mice improves neuromuscular junction innervation and function CC Iyer, D Chugh, PJ Bobbili, AJ Blatnik III, AE Crum, FY Allen, BK Kaspar, ... Neurobiology of aging 104, 32-41, 2021 | 10 | 2021 |
Conditional deletion of SMN in cell culture identifies functional SMN alleles AJ Blatnik III, VL McGovern, TT Le, CC Iyer, BK Kaspar, AHM Burghes Human Molecular Genetics 29 (21), 3477-3492, 2020 | 10 | 2020 |
SMN blood levels in a porcine model of spinal muscular atrophy C Iyer, X Wang, SR Renusch, SI Duque, AM Wehr, XM Mo, VL McGovern, ... Journal of neuromuscular diseases 4 (1), 59-66, 2017 | 10 | 2017 |
Voluntary wheel running with and without follistatin overexpression improves NMJ transmission but not motor unit loss in late life of C57BL/6J mice D Chugh, CC Iyer, P Bobbili, AJ Blatnik III, BK Kaspar, K Meyer, ... Neurobiology of aging 101, 285-296, 2021 | 6 | 2021 |
Intragenic complementation of amino and carboxy terminal SMN missense mutations can rescue Smn null mice VL McGovern, KM Kray, WD Arnold, SI Duque, CC Iyer, ... Human Molecular Genetics 29 (21), 3493-3503, 2020 | 5 | 2020 |
Identification of functional SMNs and suppressors of SMA causing mutations to define the critical function of SMN that causes SMA A Burghes, A Blatnik III, C Ruhno, V McGovern, T Le, V Pessino, S Driscoll, ... NEUROMUSCULAR DISORDERS 30, S99-S99, 2020 | | 2020 |
SMA: REGISTRIES, BIOMARKERS & OUTCOME MEASURES: P. 180 Identification of functional SMNs and suppressors of SMA causing mutations to define the critical function of SMN that … A Burghes, A Blatnik, C Ruhno, V McGovern, T Le, V Pessino, S Driscoll, ... Neuromuscular Disorders 30, S99, 2020 | | 2020 |