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Rowan Flynn
Rowan Flynn
Roslin Cell Therapies
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Jahr
LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages
A Härtlova, S Herbst, J Peltier, A Rodgers, O Bilkei‐Gorzo, A Fearns, ...
The EMBO journal 37 (12), e98694, 2018
1642018
CRISPR-mediated genotypic and phenotypic correction of a chronic granulomatous disease mutation in human iPS cells
R Flynn, A Grundmann, P Renz, W Hänseler, WS James, SA Cowley, ...
Experimental hematology 43 (10), 838-848. e3, 2015
1612015
Alpha-synuclein induces the unfolded protein response in Parkinson’s disease SNCA triplication iPSC-derived neurons
SM Heman-Ackah, R Manzano, JJM Hoozemans, W Scheper, R Flynn, ...
Human molecular genetics 26 (22), 4441-4450, 2017
1412017
Correction of the ΔF508 mutation in the cystic fibrosis transmembrane conductance regulator gene by zinc-finger nuclease homology-directed repair
CM Lee, R Flynn, JA Hollywood, MF Scallan, PT Harrison
BioResearch open access 1 (3), 99-108, 2012
1382012
LRRK2 is recruited to phagosomes and co-recruits RAB8 and RAB10 in human pluripotent stem cell-derived macrophages
H Lee, R Flynn, I Sharma, E Haberman, PJ Carling, FJ Nicholls, ...
Stem Cell Reports 14 (5), 940-955, 2020
782020
Correction of amyotrophic lateral sclerosis related phenotypes in induced pluripotent stem cell-derived motor neurons carrying a hexanucleotide expansion mutation in C9orf72 by …
NA Ababneh, J Scaber, R Flynn, A Douglas, P Barbagallo, A Candalija, ...
Human molecular genetics 29 (13), 2200-2217, 2020
462020
The current state of naïve human pluripotency
BT Dodsworth, R Flynn, SA Cowley
Stem Cells 33 (11), 3181-3186, 2015
452015
Expression of apolipoprotein AI in rabbit carotid endothelium protects against atherosclerosis
R Flynn, K Qian, C Tang, N Dronadula, JM Buckler, B Jiang, S Wen, ...
Molecular Therapy 19 (10), 1833-1841, 2011
332011
Helper-dependent adenoviral vectors are superior in vitro to first-generation vectors for endothelial cell-targeted gene therapy
R Flynn, JM Buckler, C Tang, F Kim, DA Dichek
Molecular Therapy 18 (12), 2121-2129, 2010
212010
Application of CRISPR/Cas9 editing and digital droplet PCR in human iPSCs to generate novel knock-in reporter lines to visualize dopaminergic neurons
C Überbacher, J Obergasteiger, M Volta, S Venezia, S Müller, I Pesce, ...
Stem cell research 41, 101656, 2019
172019
Construction of a novel expression cassette for increasing transgene expression in vivo in endothelial cells of large blood vessels
N Dronadula, L Du, R Flynn, J Buckler, J Kho, Z Jiang, S Tanaka, ...
Gene therapy 18 (5), 501-508, 2011
162011
Profiling of naïve and primed human pluripotent stem cells reveals state-associated miRNAs
BT Dodsworth, K Hatje, M Rostovskaya, R Flynn, CA Meyer, SA Cowley
Scientific Reports 10 (1), 10542, 2020
142020
Overexpression of endothelial nitric oxide synthase improves endothelium-dependent vasodilation in arteries infused with helper-dependent adenovirus
B Jiang, L Du, R Flynn, N Dronadula, J Zhang, F Kim, D Dichek
Human gene therapy 23 (11), 1166-1175, 2012
72012
Improved animal models for testing gene therapy for atherosclerosis
L Du, J Zhang, GRY De Meyer, R Flynn, DA Dichek
Human Gene Therapy Methods 25 (2), 106-114, 2014
62014
Development of PCR conditions in a silicon microreactor DNA-amplification device
MH Hofmann, A Akkoyun, R Flynn, A Mathewson, H Berney, MM Sheehan
International Journal of Environmental Analytical Chemistry 84 (11), 821-833, 2004
52004
Rates of homology directed repair of CRISPR-Cas9 induced double strand breaks are lower in naïve compared to primed human pluripotent stem cells
BT Dodsworth, K Hatje, CA Meyer, R Flynn, SA Cowley
Stem Cell Research 46, 101852, 2020
32020
Correction> 80% of CF Causing Mutations in CF Cells Using ZFN Homology-Directed Repair
JA Hollywood, CM Lee, K Kaschig, R Flynn, MF Scallan, PT Harrison
IRISH JOURNAL OF MEDICAL SCIENCE 185, S36-S37, 2016
2016
Efficiency of CRISPR-Cas9 is also its downfall: Implications for footprintless gene editing of disease causing mutations
R Flynn, A Grundmann, M Moore, S Cowley
HUMAN GENE THERAPY 26 (9), A30-A31, 2015
2015
Gene editing in naive human pluripotent stem cells
B Dodsworth, R Flynn, CA Meyer, S Cowley
HUMAN GENE THERAPY 26 (9), A30-A30, 2015
2015
CRISPR-mediated Genotypic and Phenotypic Correction of a Chronic Granulomatous Disease
R Flynn, A Grundmann, P Renz, W Haenseler, WS James, SA Cowley, ...
2015
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